Should I really be concerned about artificial sweeteners harming my body? Artificial sweeteners have been found to be one of the most toxic substances we can put inside our bodies. Besides the fact that it causes brain and metabolism dysfunction, they clog up your liver to a point where it can not fully function. Why is your liver so important? Your liver is not only responsible for eliminating toxins from your body but it is also responsible for metabolizing fat. If it is so busy processing through artificial sweeteners (a harmful toxin), it will not spend a sufficient amount of time processing through the unwanted fat you are trying to lose.